The impact of non-neutral synonymous mutations when inferring selection on nonsynonymous mutations.

Abstract excerpt

The distribution of fitness effects (DFE) describes the proportions of new mutations that have different effects on fitness. Accurate measurements of the DFE are important because the DFE is a fundamental parameter in evolutionary genetics and has implications for understanding of other phenomena such as complex disease or inbreeding depression. Current computational methods to infer the DFE for nonsynonymous...

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