Article
The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals.
PLoS biology - 1 Sept 2026
Lin Meixi, Chakraborty Sneha, Amorim Carlos Eduardo G, Nigenda-Morales Sergio F, Beichman Annabel C, Nuñez-Valencia Paulina G, Mah Jonathan C, Robinson Jacqueline A, Kyriazis Christopher C, Huber Christian D, Webb Andrew E, Kocher Sarah D, Archer Frederick I, Moreno-Estrada Andrés, Wayne Robert K, Lohmueller Kirk E
Abstract excerpt
The distribution of fitness effects (DFE) describes the selection coefficients of newly arising mutations and fundamentally influences population genetic processes. However, the extent and mechanisms of differences in the DFE for non-synonymous mutations have not been systematically investigated across species with divergent phylogenetic histories and ecologies. Here, we inferred the DFE in natural populations of...
Read the complete abstract on PubMedTopics
- Animals
- Phylogeny
- Genetic Fitness
- Mutation
- Humans