Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haemophilus ducreyi targets Src family protein tyrosine kinases to inhibit phagocytic signaling.

Infection and immunity - 1 Dec 2005

Mock Jason R, Vakevainen Merja, Deng Kaiping, Latimer Jo L, Young Jennifer A, van Oers Nicolai S C, Greenberg Steven, Hansen Eric J

Abstract excerpt

Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, has been shown to inhibit phagocytosis of both itself and secondary targets in vitro. Immunodepletion of LspA proteins from H. ducreyi culture supernatant fluid abolished this inhibitory effect, indicating that the LspA proteins are necessary for the inhibition of phagocytosis by H. ducreyi. Fluorescence microscopy revealed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Bacterial
Share to Catalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lectins

Share to Macrophages

Share to Phagocytosis

Share to Phosphoproteins

Share to Receptors, IgG

Share to src-Family Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 16299270
DOI: 10.1128/IAI.73.12.7808-7816.2005
PMCID: PMC1307070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haemophilus ducreyi targets Src family protein tyrosine kinases to inhibit phagocytic signaling.PMID 16299270Read ↗

Expression of the LspA1 and LspA2 proteins by Haemophilus ducreyi is required for virulence in human volunteers.Semantic proximity Read ↗

Integrin-mediated Invasion of Staphylococcus aureus into Human Cells Requires Src Family Protein-tyrosine KinasesSemantic proximity Read ↗

Src kinase has a central role in in vitro cellular internalization of Staphylococcus aureus.Semantic proximity Read ↗

Binding of IgG-opsonized particles to Fc gamma R is an active stage of phagocytosis that involves receptor clustering and phosphorylation.Semantic proximity Read ↗

Localization of the Yersinia PTPase to focal complexes is an important virulence mechanism.Semantic proximity Read ↗

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.Semantic proximity Read ↗

Mutations in the lspA1 and lspA2 genes of Haemophilus ducreyi affect the virulence of this pathogen in an animal model system.Semantic proximity Read ↗

Src kinases central to T-cell receptor signaling regulate TLR-activated innate immune responses from human T cells.Semantic proximity Read ↗

Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages.Semantic proximity Read ↗

Fc receptor-mediated phagocytosis requires CDC42 and Rac1.Semantic proximity Read ↗

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.Semantic proximity Read ↗

Enhancement of fcgamma receptor-mediated phagocytosis by transforming mutants of Cbl.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.