Article
Integrin-mediated Invasion of Staphylococcus aureus into Human Cells Requires Src Family Protein-tyrosine Kinases
1 Oct 2003
Abstract excerpt
Staphylococcus aureus, a common cause of nosocomial infections, is able to invade eukaryotic cells by indirectly engaging beta1 integrin-containing host receptors, whereas non-pathogenic Staphylococcus carnosus is not invasive. Here, we identify intracellular signals involved in integrin-initiated internalization of S. aureus. In particular, the host cell actin cytoskeleton and Src family protein-tyrosine kinases...
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