Article
Chloroquine-treatment failure in northern Ghana: roles of pfcrt T76 and pfmdr1 Y86.
Annals of tropical medicine and parasitology - 1 Dec 2005
Mockenhaupt F P, Ehrhardt S, Eggelte T A, Agana-Nsiire P, Stollberg K, Mathieu A, Markert M, Otchwemah R N, Bienzle U
Abstract excerpt
Although chloroquine (CQ) monotherapy is now generally inadequate for the treatment of Plasmodium falciparum malaria in northern Ghana--recently, 58% of 225 children failed treatment by day 14--use of the drug continues because of its low cost and wide availability. The risk factors associated with CQ-treatment failure in this region of Africa, including the T76 mutation in the chloroquine resistance transporter...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Antimalarials
- Child
- Child, Preschool
- Chloroquine
- Drug Resistance, Microbial
- Female
- Humans
- Infant
- Infant, Newborn
- Malaria, Falciparum
- Male
- Malnutrition