Article
Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria.
The American journal of tropical medicine and hygiene - 1 Jul 2006
Happi C T, Gbotosho G O, Folarin O A, Bolaji O M, Sowunmi A, Kyle D E, Milhous W, Wirth D F, Oduola A M J
Abstract excerpt
This study investigated the association between Plasmodium falciparum chloroquine resistance transporter (pfcrt) T76 and P. falciparum multidrug resistance gene 1 (pfmdr1) Y86 alleles and in vivo amodiaquine (AQ) resistance, as well as the clearance of parasites harboring these two alleles in children treated with AQ in southwest Nigeria. One hundred one children with acute uncomplicated P. falciparum malaria...
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