Article
Role of the pfcrt codon 76 mutation as a molecular marker for population-based surveillance of chloroquine (CQ)-resistant Plasmodium falciparum malaria in Ugandan sentinel sites with high CQ resistance.
Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Jan 2000
Talisuna Ambrose O, Kyosiimire-Lugemwa Jackie, Langi Peter, Mutabingwa Theonest K, Watkins William, Van Marck Eric, Egwang Thomas, D'Alessandro Umberto
Abstract excerpt
The mutant genotype at codon 76 of the pfcrt gene (T76) has been proposed as a molecular marker for surveillance of chloroquine (CQ)-resistant Plasmodium falciparum malaria but this proposal has not been validated by population-based surveys. In 1998-99, in 6 Ugandan sentinel sites, the prevalence of P. falciparum infections with the T76 genotype and the level of CQ use were measured by community surveys, and CQ...
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