Article
Mutations in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance genes, and treatment outcomes in Ghanaian children with uncomplicated malaria.
Journal of tropical pediatrics - 1 Feb 2007
Duah Nancy O, Wilson Michael D, Ghansah Anita, Abuaku Ben, Edoh Dominic, Quashie Neils B, Koram Kwadwo A
Abstract excerpt
The association between the clinical outcome of chloroquine treatment and mutations in the putative Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene at codon 76 and multidrug resistance gene 1 (Pf mdr1) at codon 86 were investigated among 406 children with uncomplicated malaria presenting at five sentinel health centres in Ghana. Presence of mutations in isolates taken at pre-treatment and on...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Antimalarials
- Chi-Square Distribution
- Child, Preschool
- Chloroquine
- Codon
- Drug Resistance, Multiple
- Female
- Genes, Protozoan