Article
The roles of the pfcrt 76T and pfmdr1 86Y mutations, immunity and the initial level of parasitaemia, in predicting the outcome of chloroquine treatment in two areas with different transmission intensities.
Annals of tropical medicine and parasitology - 1 Jul 2005
Khalil I F, Alifrangis M, Tarimo D S, Staalsø T, Satti G M H, Theander T G, Rønn A M, Bygbjerg I C
Abstract excerpt
The resistance of Plasmodium falciparum to chloroquine (CQ) is probably mediated by point mutations in two genes: pfcrt and pfmdr1. The aim of the present study was to investigate, in patients treated with CQ, the association between host factors, such as immunity and initial level of parasitaemia, and the ability to clear P. falciparum parasites carrying the key chloroquine-resistance (CQR) mutations, pfcrt 76T...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.