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Article

Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana.

Antimicrobial agents and chemotherapy - 1 Sept 2007

Ehrhardt Stephan, Eggelte Teunis A, Kaiser Sarah, Adjei Lydia, Burchard Gerd D, Anemana Sylvester D, Bienzle Ulrich, Mockenhaupt Frank P

Abstract excerpt

Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in...

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Identifiers

PMID: 17562799
DOI: 10.1128/AAC.00179-07
PMCID: PMC2043215

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