Article
Concordance of pharmacogenetic markers in germline and colorectal tumor DNA.
Pharmacogenomics - 1 Dec 2005
Marsh Sharon, Mallon Mary Ann, Goodfellow Paul, McLeod Howard L
Abstract excerpt
INTRODUCTION: Most cancer pharmacogenetic studies use germline DNA, as tumor tissue is often inaccessible in the advanced disease setting. However, this relies on the assumption that germline DNA is representative of the tumor genotype. To date, there has been little attention paid to defining the relationship between tumor and germline genomes. MATERIALS AND METHODS: This study compared 28 polymorphisms in 13...
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