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Article

Germline genetic variation, cancer outcome, and pharmacogenetics.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Sept 2010

Coate Linda, Cuffe Sinead, Horgan Anne, Hung Rayjean J, Christiani David, Liu Geoffrey

Abstract excerpt

Studies of the role of germline or inherited genetic variation on cancer outcome can fall into three distinct categories. First, the impact of highly penetrant but lowly prevalent mutations of germline DNA on cancer prognosis has been studied extensively for BRCA1 and BRCA2 mutations as well as mutations related to hereditary nonpolyposis colorectal cancer syndrome. These mainly modest-sized analyses have...

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Source

Identifiers

PMID: 20679599
DOI: 10.1200/JCO.2009.27.2336

Genes

BRCA1
BRCA2
DPYD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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