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Article

Sim1 and Sim2 are required for the correct targeting of mammillary body axons.

Development (Cambridge, England) - 1 Dec 2005

Marion Jean-François, Yang Chun, Caqueret Aurore, Boucher Francine, Michaud Jacques L

Abstract excerpt

The mammillary body (MB), and its axonal projections to the thalamus (mammillothalamic tract, MTT) and the tegmentum (mammillotegmental tract, MTEG), are components of a circuit involved in spatial learning. The bHLH-PAS transcription factors SIM1 and SIM2 are co-expressed in the developing MB. We have found that MB neurons are generated and that they survive at least until E18.5 in embryos lacking both Sim1 and...

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Source

Identifiers

PMID: 16291793
DOI: 10.1242/dev.02142

Genes

ROBO1
SIM1
SIM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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