Article
The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells.
Cell - 5 Oct 1990
Nambu J R, Franks R G, Hu S, Crews S T
Abstract excerpt
The single-minded (sim) gene of Drosophila encodes a nuclear protein that plays a critical role in the development of the neurons, glia, and other nonneuronal cells that lie along the midline of the embryonic CNS. Using distinct cell fate markers, we observe that in sim mutant embryos the midline cells fail to differentiate properly into their mature CNS cell types and do not take their appropriate positions...
Topics
- Animals
- Drosophila
- Embryo, Nonmammalian
- Gene Expression Regulation
- Genes
- Mutation
- Nervous System
- Phenotype