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Article

Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn.

Development (Cambridge, England) - 1 Dec 2005

Glasgow Stacey M, Henke R Michael, Macdonald Raymond J, Wright Christopher V E, Johnson Jane E

Abstract excerpt

Mutations in the human and mouse PTF1A/Ptf1a genes result in permanent diabetes mellitus and cerebellar agenesis. We show that Ptf1a is present in precursors to GABAergic neurons in spinal cord dorsal horn as well as the cerebellum. A null mutation in Ptf1a reveals its requirement for the dorsal horn GABAergic neurons. Specifically, Ptf1a is required for the generation of early-born (dI4, E10.5) and late-born...

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Source

Identifiers

PMID: 16291784
DOI: 10.1242/dev.02167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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