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Article

Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons.

Genes & development - 1 May 2020

Mona Bishakha, Villarreal Juan, Savage Trisha K, Kollipara Rahul K, Boisvert Brooke E, Johnson Jane E

Abstract excerpt

Peripheral somatosensory input is modulated in the dorsal spinal cord by a network of excitatory and inhibitory interneurons. PTF1A is a transcription factor essential in dorsal neural tube progenitors for specification of these inhibitory neurons. Thus, mechanisms regulating Ptf1a expression are key for generating neuronal circuits underlying somatosensory behaviors. Mutations targeted to distinct cis-regulatory...

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Identifiers

PMID: 32241803
DOI: 10.1101/gad.332577.119
PMCID: PMC7197352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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