Article
A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry.
Cell reports - 17 Oct 2017
Zhang Juliet, Weinrich Jarret A P, Russ Jeffrey B, Comer John D, Bommareddy Praveen K, DiCasoli Richard J, Wright Christopher V E, Li Yuqing, van Roessel Peter J, Kaltschmidt Julia A
Abstract excerpt
Spinal interneurons are critical modulators of motor circuit function. In the dorsal spinal cord, a set of interneurons called GABApre presynaptically inhibits proprioceptive sensory afferent terminals, thus negatively regulating sensory-motor signaling. Although deficits in presynaptic inhibition have been inferred in human motor diseases, including dystonia, it remains unclear whether GABApre circuit components...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.