Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates.

doi:10.1021/bi9611220

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Article

Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates.

Biochemistry - 20 Aug 1996

Hosea N A, Radić Z, Tsigelny I, Berman H A, Quinn D M, Taylor P

Abstract excerpt

Through site-specific mutagenesis, we examined the determinants on acetylcholinesterase which govern the specificity and reactivity of three classes of substrates: enantiomeric alkyl phosphonates, trifluoromethyl acetophenones, and carboxyl esters. By employing cationic and uncharged pairs of enantiomeric alkyl methylphosphonyl thioates of known absolute stereochemistry, we find that an aspartate residue near the...

Topics

Acetylcholinesterase
Animals
Aspartic Acid
Cations
Cell Line
Cholinesterase Inhibitors
Diffusion
Electrochemistry
Humans
Mutation
Organophosphorus Compounds
Stereoisomerism
Substrate Specificity
Torpedo

Source

Open in PubMed

Identifiers

PMID: 8718893
DOI: 10.1021/bi9611220

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