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Article

Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.

Cancer letters - 28 Aug 2006

Ma Hongxia, Hu Zhibin, Zhai Xiangjun, Wang Shui, Wang Xuechen, Qin Jianwei, Jin Guangfu, Liu Jiyong, Wang Xinru, Wei Qingyi, Shen Hongbing

Abstract excerpt

MDM2 is a phosphoprotein that interacts with P53 and inhibits its activity. Recently, a T/G substitution (SNP309) in the promoter of MDM2 was identified and has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including breast cancer. To test the hypothesis that this functional variant in the MDM2 promoter is associated with risk of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16288830
DOI: 10.1016/j.canlet.2005.09.019

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.PMID 16288830Read ↗

A case-control study on the SNP309T → G and 40-bp Del1518 of the MDM2 gene and a systematic review for MDM2 polymorphisms in the patients with breast cancer.Semantic proximity Read ↗

Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk.Semantic proximity Read ↗

MDM2 SNP309 polymorphism and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer.Semantic proximity Read ↗

Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish PopulationSemantic proximity Read ↗

MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis.Semantic proximity Read ↗

MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.Semantic proximity Read ↗

MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis.Semantic proximity Read ↗

Association of breast cancer outcome with status of p53 and MDM2 SNP309.Semantic proximity Read ↗

No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites.Semantic proximity Read ↗

Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population.Semantic proximity Read ↗

MDM2 SNP309 and cancer risk: a combined analysis.Semantic proximity Read ↗

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