Article
SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae.
Genes & development - 1 Jul 1992
Eisenmann D M, Arndt K M, Ricupero S L, Rooney J W, Winston F
Abstract excerpt
Mutations in the Saccharomyces cerevisiae gene SPT15, which encodes the TATA-binding protein TFIID, have been shown to cause pleiotropic phenotypes and to lead to changes in transcription in vivo. Here, we report the cloning and analysis of one such mutation, spt15-21, which causes a single-amino-acid substitution in a conserved residue of TFIID. Surprisingly, the spt15-21 mutation does not affect the stability...
Topics
- Amino Acid Sequence
- Fungal Proteins
- Introns
- Molecular Sequence Data
- Multigene Family
- Mutation
- Precipitin Tests
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Suppression, Genetic
- Transcription Factor TFIID