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Article

Biochemical and genetic characterization of a yeast TFIID mutant that alters transcription in vivo and DNA binding in vitro.

Molecular and cellular biology - 1 May 1992

Arndt K M, Ricupero S L, Eisenmann D M, Winston F

Abstract excerpt

A mutation in the gene that encodes Saccharomyces cerevisiae TFIID (SPT15), which was isolated in a selection for mutations that alter transcription in vivo, changes a single amino acid in a highly conserved region of the second direct repeat in TFIID. Among eight independent spt15 mutations, seven cause this same amino acid change, Leu-205 to Phe. The mutant TFIID protein (L205F) binds with greater affinity than...

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Identifiers

PMID: 1569955
DOI: 10.1128/mcb.12.5.2372-2382.1992
PMCID: PMC364409

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Biochemical and genetic characterization of a yeast TFIID mutant that alters transcription in vivo and DNA binding in vitro.PMID 1569955Read ↗

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