Article
Evidence that Spt3 functionally interacts with Mot1, TFIIA, and TATA-binding protein to confer promoter-specific transcriptional control in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jan 1997
Madison J M, Winston F
Abstract excerpt
Spt3 of Saccharomyces cerevisiae is a factor required for normal transcription from particular RNA polymerase II-dependent promoters. Previous genetic and biochemical analyses have shown that Spt3 interacts with the yeast TATA-binding protein (TBP). To identify other factors that might interact with Spt3, we have screened for mutations that, in combination with an spt3 null mutation, lead to inviability. In this...
Topics
- Adenosine Triphosphatases
- DNA Helicases
- DNA-Binding Proteins
- Fungal Proteins
- Gene Expression
- Genes, Fungal
- Genes, Lethal
- Mutation
- Promoter Regions, Genetic
- RNA, Fungal
- RNA, Messenger
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins