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Article

The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters.

Molecular and cellular biology - 1 Dec 1996

Collart M A

Abstract excerpt

Previous studies demonstrated that mutations in the Saccharomyces cerevisiae NOT genes increase transcription from TATA-less promoters. In this report, I show that in contrast, mutations in the yeast MOT1 gene decrease transcription from TATA-less promoters. I also demonstrate specific genetic interactions between the Not complex, Mot1p, and another global regulator of transcription in S. cerevisiae, Spt3p. Five...

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Source

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Identifiers

PMID: 8943321
DOI: 10.1128/MCB.16.12.6668
PMCID: PMC231669

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters.PMID 8943321Read ↗

Evidence that Spt3 functionally interacts with Mot1, TFIIA, and TATA-binding protein to confer promoter-specific transcriptional control in Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of NOT5 that encodes a new component of the Not protein complex.Semantic proximity Read ↗

Genome-wide transcriptional dependence on conserved regions of Mot1.Semantic proximity Read ↗

Identification and analysis of Mot3, a zinc finger protein that binds to the retrotransposon Ty long terminal repeat (delta) in Saccharomyces cerevisiae.Semantic proximity Read ↗

The TATA-binding protein-associated factor yTafII19p functionally interacts with components of the global transcriptional regulator Ccr4-Not complex and physically interacts with the Not5 subunit.Semantic proximity Read ↗

A SAGA-independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-not complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.Semantic proximity Read ↗

Transcriptional corepression in vitro: a Mot1p-associated form of TATA-binding protein is required for repression by Leu3p.Semantic proximity Read ↗

Genetic analysis connects SLX5 and SLX8 to the SUMO pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

TATA-binding protein variants that bypass the requirement for Mot1 in vivo.Semantic proximity Read ↗

SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation.Semantic proximity Read ↗

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