Article
Allelic imbalances in human bladder cancer: genome-wide detection with high-density single-nucleotide polymorphism arrays.
Journal of the National Cancer Institute - 6 Feb 2002
Primdahl Hanne, Wikman Friedrik P, von der Maase Hans, Zhou Xiao-ge, Wolf Hans, Orntoft Torben F
Abstract excerpt
BACKGROUND: Bladder cancer is characterized by genomic instability. In this study, we investigated whether genome-wide screening using single-nucleotide polymorphism (SNP) arrays could detect allelic imbalance (loss or gain of at least one allele) in bladder cancers. METHODS: For microarray analysis, DNA was isolated from microdissected bladder tumors and leukocytes from 11 patients. The stage T1 tumor...
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