Article
Genome-wide detection of allelic imbalance using human SNPs and high-density DNA arrays.
Genome research - 1 Aug 2000
Mei R, Galipeau P C, Prass C, Berno A, Ghandour G, Patil N, Wolff R K, Chee M S, Reid B J, Lockhart D J
Abstract excerpt
Most human cancers are characterized by genomic instability, the accumulation of multiple genetic alterations and allelic imbalance throughout the genome. Loss of heterozygosity (LOH) is a common form of allelic imbalance and the detection of LOH has been used to identify genomic regions that harbor tumor suppressor genes and to characterize tumor stages and progression. Here we describe the use of high-density...
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