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Article

Control of Multidrug Resistance Gene <i>mdr1</i> and Cancer Resistance to Chemotherapy by the Longevity Gene <i>sirt1</i>

15 Nov 2005

Abstract excerpt

Irreversible growth arrest (also called senescence) has emerged recently as a tumor suppressor mechanism and a key determinant of cancer chemotherapy outcome. Previous work from our laboratory suggested that the cellular ability to undergo or to escape senescence dictates its fate to become drug-sensitive or drug-resistant, respectively. In the present study, we made the hypothesis that longevity genes, by virtue...

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PMID: 16288004
DOI: 10.1158/0008-5472.can-05-2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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