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Article

SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells

28 Jun 2017

Abstract excerpt

BACKGROUND: SIRT1 is a longevity gene that forestalls aging and age-related diseases including cancer, and has recently attracted widespread attention due to its overexpression in some cancers. We previously identified the overexpression of SIRT1 in ovarian carcinoma (OvCa) as a poor prognostic factor. However, mechanistic insights into the function of SIRT1 in OvCa have yet to be elucidated. METHODS:...

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PMID: 28667895
DOI: 10.1016/j.tranon.2017.05.005

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