Article
Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity.
Molecular cancer therapeutics - 1 Jul 2008
Sullivan Richard, Paré Geneviève C, Frederiksen Lisa J, Semenza Gregg L, Graham Charles H
Abstract excerpt
Hypoxia in solid tumors is associated with the development of chemoresistance. Although many studies have focused on the effect of hypoxia on drug-induced apoptosis, the effect of nonapoptotic pathways on hypoxia-induced drug resistance has not been previously investigated. Here, we determined the effects of hypoxia on multiple forms of drug-induced death in human MDA-MB-231 breast carcinoma cells. Clonogenic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.