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Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status

27 May 2016

Abstract excerpt

Sirtuins (SIRT) belonging to the NAD+ dependent histone deacetylase III class of enzymes have emerged as master regulators of metabolism and longevity. However, their role in prevention of organismal aging and cellular senescence still remains controversial. In the present study, we now report upregulation of SIRT2 as a specific feature associated with stress induced premature senescence but not with either...

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PMID: 27229617
DOI: 10.1080/15384101.2016.1189041

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