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Article

Emerging Roles of SIRT1 in Cancer Drug Resistance

17 Jan 2013

Abstract excerpt

Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years, acquired resistance has emerged as a daunting challenge to targeted cancer therapy, which abolishes the efficacy of otherwise successful targeting drugs. Cancer cells gain the resistance property through a variety of mechanisms in primary and metastatic cancers, involving cellular intrinsic and extrinsic factors....

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PMID: 24019998
DOI: 10.1177/1947601912473826

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