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Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205.

Cell cycle (Georgetown, Tex.) - 15 Mar 2012

Cufí Sílvia, Vazquez-Martin Alejandro, Oliveras-Ferraros Cristina, Quirantes Rosa, Segura-Carretero Antonio, Micol Vicente, Joven Jorge, Bosch-Barrera Joaquim, Del Barco Sonia, Martin-Castillo Begoña, Vellon Luciano, Menendez Javier A

Abstract excerpt

We have tested the hypothesis that the antidiabetic biguanide metformin can be used to manipulate the threshold for stress-induced senescence (SIS), thus accelerating the onset of cancer-protective cellular senescence in response to oncogenic stimuli. Using senescence-prone murine embryonic fibroblasts (MEFs), we assessed whether metformin treatment modified the senescence phenotype that is activated in response...

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PMID: 22356767
DOI: 10.4161/cc.11.6.19665

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