Article

RNAa-Mediated Epigenetic Attenuation of The Cell Senescence via Locus Specific Induction of Endogenous SIRT1

2021-10-05

Abstract excerpt

SIRT1, a known regulator of cellular senescence, is a therapeutic target for age related disorders and its upregulation is a strategy to improve the cell therapeutic potentials of human mesenchymal stem cell (MSCs). Knockdown of natural antisense transcripts via small activating RNAs (RNAa) is an emerging approach for safe and locus specific gene regulation. We have recently identified a natural antisense transcri...

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Literature Corpus work: b14885b4-fe58-55eb-8295-a232d1151225
DOI: 10.21203/rs.3.rs-917721/v1

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