Article
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.
Cell cycle (Georgetown, Tex.) - 15 Jan 2013
Han Jeehae, Hubbard Basil P, Lee Jaehoon, Montagna Cristina, Lee Han-Woong, Sinclair David A, Suh Yousin
Abstract excerpt
SIRT1 is an evolutionarily conserved protein deacetylase that modulates stress response, cellular metabolism and aging in model organisms. While SIRT1 exerts beneficial effects in protecting against age-related diseases, the role of SIRT1 in cancer has been controversial. SIRT1 promotes cell survival by deacetylating, and thereby negatively regulating the activity of important tumor suppressors such as p53. In...
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