Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background.

Cancer research - 15 Nov 2005

Wilson Catherine, Idziaszczyk Shelley, Colley James, Humphreys Vikki, Guy Carol, Maynard Julie, Sampson Julian R, Cheadle Jeremy P

Abstract excerpt

A Bloom's deficient mouse model (Blm(m3/m3)) has been shown to induce colorectal tumorigenesis when crossed with Apc+/Min mice. Here, we investigated whether the Blm(m3/m3) genotype could induce tumorigenesis in extracolonic tissues in tuberous sclerosis 1-deficient (Tsc1+/-) mice that are predisposed to renal cystadenomas and carcinomas. Genotyping of offspring from Tsc1+/- Blm+/m3 intercrosses showed that a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Kidney Neoplasms

Share to Loss of Heterozygosity

Share to RecQ Helicases

Share to Tuberous Sclerosis Complex 1 Protein

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 16288003
DOI: 10.1158/0008-5472.CAN-05-2688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background.PMID 16288003Read ↗

Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice.Semantic proximity Read ↗

Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM).Semantic proximity Read ↗

Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder.Semantic proximity Read ↗

Enhanced tumor formation in mice heterozygous for Blm mutation.Semantic proximity Read ↗

A germ-line <i>Tsc1</i> mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by <i>Tsc2</i> mutation in miceSemantic proximity Read ↗

Chromosome instability and tumor predisposition inversely correlate with BLM protein levels.Semantic proximity Read ↗

Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat.Semantic proximity Read ↗

Disappearance of polycystic kidney disease in revertant c-myc transgenic mice.Semantic proximity Read ↗

Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanismsSemantic proximity Read ↗

Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression.Semantic proximity Read ↗

Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure.Semantic proximity Read ↗

Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.