Article
Enhanced tumor formation in mice heterozygous for Blm mutation.
Science (New York, N.Y.) - 20 Sept 2002
Goss Kathleen Heppner, Risinger Mary A, Kordich Jennifer J, Sanz Maureen M, Straughen Joel E, Slovek Lisa E, Capobianco Anthony J, German James, Boivin Gregory P, Groden Joanna
Abstract excerpt
Persons with the autosomal recessive disorder Bloom syndrome are predisposed to cancers of many types due to loss-of-function mutations in the BLM gene, which encodes a recQ-like helicase. Here we show that mice heterozygous for a targeted null mutation of Blm, the murine homolog of BLM, develop lymphoma earlier than wild-type littermates in response to challenge with murine leukemia virus and develop twice the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.