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Article

Chromosome instability and tumor predisposition inversely correlate with BLM protein levels.

DNA repair - 9 Dec 2003

McDaniel Lisa D, Chester Nicholas, Watson Mark, Borowsky Alexander D, Leder Philip, Schultz Roger A

Abstract excerpt

Independent mouse models for Bloom syndrome (BS) exist, each thought to disrupt Blm gene function. However, animals bearing these alleles exhibit distinct phenotypes. Blm(tm1Ches) and Blm(tm1Grdn) homozygous mutant animals exhibit embryonic lethality while in another, Blm(tm3Brd), homozygosity yields viable, fertile animals with a cancer predisposition. Further characterization reveals the Blm(tm3Brd) allele to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14642567
DOI: 10.1016/j.dnarep.2003.08.006

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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