Article
Disappearance of polycystic kidney disease in revertant c-myc transgenic mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 1994
Trudel M, Chrétien N, D'Agati V
Abstract excerpt
Nineteen SBM transgenic mouse lines specifically expressing the c-myc protooncogene in renal epithelium Transgene expression is completely penetrant, leading to death from renal failure. In the course of continuous breeding of eight transgenic lines, all lines underwent spontaneous transgene mutations characterized by partial deletion and probable rearrangement of the transgene insert. Revertant mice and their...
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