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Article

Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit.

Molecular and cellular biology - 1 Dec 2005

Stewart Scott, Fang Guowei

Abstract excerpt

TPX2, a microtubule-associated protein, is required downstream of Ran-GTP to induce spindle assembly. TPX2 activity appears to be tightly regulated during the cell cycle, and we report here one molecular mechanism for this regulation. We found that TPX2 protein levels are cell cycle regulated, peaking in mitosis and declining sharply during mitotic exit. TPX2 is degraded in mitotic extracts, as well as in HeLa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16287863
DOI: 10.1128/MCB.25.23.10516-10527.2005
PMCID: PMC1291225

Genes

TPX2
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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