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Article

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells.

Nature cell biology - 1 Nov 2002

Gruss Oliver J, Wittmann Malte, Yokoyama Hideki, Pepperkok Rainer, Kufer Thomas, Silljé Herman, Karsenti Eric, Mattaj Iain W, Vernos Isabelle

Abstract excerpt

In Xenopus laevis egg extracts, TPX2 is required for the Ran-GTP-dependent assembly of microtubules around chromosomes. Here we show that interfering with the function of the human homologue of TPX2 in HeLa cells causes defects in microtubule organization during mitosis. Suppressing the expression of human TPX2 by RNA interference leads to the formation of two microtubule asters that do not interact and do not...

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Source

Identifiers

PMID: 12389033
DOI: 10.1038/ncb870

Genes

TPX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells.PMID 12389033Read ↗

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