Article
Anaphase-promoting complex/cyclosome controls HEC1 stability.
Cell proliferation - 1 Feb 2011
Li L, Zhou Y, Wang G-F, Liao S-C, Ke Y-B, Wu W, Li X-H, Zhang R-L, Fu Y-C
Abstract excerpt
OBJECTIVE: Chromosome segregation during mitosis requires a physically large proteinaceous structure called the kinetochore to generate attachments between chromosomal DNA and spindle microtubules. It is essential for kinetochore components to be carefully regulated to guarantee successful cell division. Depletion, mutation or dysregulation of kinetochore proteins results in mitotic arrest and/or cell death. HEC1...
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