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Article

Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit.

Cell reports - 30 May 2017

Marks Daniel Henry, Thomas Rozario, Chin Yvette, Shah Riddhi, Khoo Christine, Benezra Robert

Abstract excerpt

The mitotic checkpoint ensures proper segregation of chromosomes by delaying anaphase until all kinetochores are bound to microtubules. This inhibitory signal is composed of a complex containing Mad2, which inhibits anaphase progression. The complex can be disassembled by p31comet and TRIP13; however, TRIP13 knockdown has been shown to cause only a mild mitotic delay. Overexpression of checkpoint genes, as well...

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Source

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Identifiers

PMID: 28564602
DOI: 10.1016/j.celrep.2017.05.021
PMCID: PMC5526606

Genes

TRIP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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