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Article

Control of Aurora-A stability through interaction with TPX2

9 Dec 2010

Abstract excerpt

The Aurora-A kinase has well-established roles in spindle assembly and function and is frequently overexpressed in tumours. Its abundance is cell cycle regulated, with a peak in G2 and M phases, followed by regulated proteolysis at the end of mitosis. The microtubule-binding protein TPX2 plays a major role in regulating the activity and localisation of Aurora-A in mitotic cells. Here, we report a novel regulatory...

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Identifiers

PMID: 21147853
DOI: 10.1242/jcs.075457

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