Article
A refined atomic scale model of the Saccharomyces cerevisiae K+-translocation protein Trk1p combined with experimental evidence confirms the role of selectivity filter glycines and other key residues.
Biochimica et biophysica acta - 1 May 2015
Zayats Vasilina, Stockner Thomas, Pandey Saurabh Kumar, Wörz Katharina, Ettrich Rüdiger, Ludwig Jost
Abstract excerpt
Potassium ion (K+) uptake in yeast is mediated mainly by the Trk1/2 proteins that enable cells to survive on external K+ concentration as low as a few μM. Fungal Trks are related to prokaryotic TRK and Ktr and plant HKT K+ transport systems. Overall sequence similarity is very low, thus requiring experimental verification of homology models. Here a refined structural model of the Saccharomyces cerevisiae Trk1 is...
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