Article
Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer.
International journal of cancer - 1 Aug 2006
Lind Helge, Zienolddiny Shanbeh, Ekstrøm Per Olav, Skaug Vidar, Haugen Aage
Abstract excerpt
Lung cancer is the leading cause of cancer mortality in the world. Although exposure to carcinogens is considered to be the main cause, genetic variation may contribute to lung cancer risk. Murine double minute 2, MDM2, is a key regulator of p53 activity and recently a polymorphism in the promote...
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