Article
Isolation and high-throughput sequencing of two closely linked epistatic hypertension susceptibility loci with a panel of bicongenic strains.
Physiological genomics - 15 Aug 2013
Pillai Resmi, Waghulde Harshal, Nie Ying, Gopalakrishnan Kathirvel, Kumarasamy Sivarajan, Farms Phyllis, Garrett Michael R, Atanur Santosh S, Maratou Klio, Aitman Timothy J, Joe Bina
Abstract excerpt
Interactions or epistasis between genetic factors may contribute to "missing heritability." While linkage analyses detect epistasis, defining the limits of the interacting segments poses a significant challenge especially when the interactions are between loci in close proximity. The goal of the present study was to isolate two such epistatic blood pressure (BP) loci on rat chromosome 5. A panel of S.LEW...
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