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Article

Genome-wide binding map of the histone deacetylase Rpd3 in yeast.

Nature genetics - 1 Jul 2002

Kurdistani Siavash K, Robyr Daniel, Tavazoie Saeed, Grunstein Michael

Abstract excerpt

We describe the genome-wide distribution of the histone deacetylase and repressor Rpd3 and its associated proteins Ume1 and Ume6 in Saccharomyces cerevisiae. Using a new cross-linking protocol, we found that Rpd3 binds upstream of many individual genes and upstream of members of gene classes with similar functions in anabolic processes. In addition, Rpd3 is preferentially associated with promoters that direct...

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Identifiers

PMID: 12089521
DOI: 10.1038/ng907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genome-wide binding map of the histone deacetylase Rpd3 in yeast.PMID 12089521Read ↗

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.Semantic proximity Read ↗

Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.Semantic proximity Read ↗

RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes.Semantic proximity Read ↗

Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.Semantic proximity Read ↗

The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development.Semantic proximity Read ↗

Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae.Semantic proximity Read ↗

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.Semantic proximity Read ↗

Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression.Semantic proximity Read ↗

Identification and characterisation of an RPD3 homologue from maize (Zea mays L.) that is able to complement an rpd3 null mutant of Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional analysis of a RPD3 histone deacetylase homologue in Arabidopsis thaliana.Semantic proximity Read ↗

Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast.Semantic proximity Read ↗

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