Article
Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1).
Infection and immunity - 1 Sept 2000
Shirin H, Sordillo E M, Kolevska T K, Hibshoosh H, Kawabata Y, Oh S H, Kuebler J F, Delohery T, Weghorst C M, Weinstein I B, Moss S F
Abstract excerpt
Helicobacter pylori infection is associated with the development of gastric cancer. In short-term coculture with AGS gastric cells, H. pylori inhibits cell cycle progression and induces dose-dependent apoptosis. Based on the concept that an imbalance between proliferation and apoptosis may contribute to the emergence of gastric cancer, we chronically exposed AGS cells to H. pylori as a model of chronic exposure...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.