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Article

Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases.

The Journal of clinical investigation - 1 Dec 2005

Li Ning, Zhao Minglang, Hilario-Vargas Julio, Prisayanh Phillip, Warren Simon, Diaz Luis A, Roopenian Derry C, Liu Zhi

Abstract excerpt

Numerous mechanisms of action have been proposed for intravenous Ig (IVIG). In this study, we used IgG passive transfer murine models of bullous pemphigoid (BP), pemphigus foliaceus (PF), and pemphigus vulgaris (PV) to test the hypothesis that the effect of IVIG in autoantibody-mediated cutaneous bullous diseases is to accelerate the degradation of pathogenic IgG by saturation of the MHC-like Fc receptor neonatal...

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Share to Autoantigens
Share to Collagen Type XVII

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Desmoglein 1

Share to Immunoglobulins, Intravenous

Share to Non-Fibrillar Collagens

Share to Pemphigoid, Bullous

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Share to Receptors, Fc

Source

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Identifiers

PMID: 16284651
DOI: 10.1172/JCI24394
PMCID: PMC1280965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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