Article
The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies.
Frontiers in immunology - 1 Jan 2021
Monnet Céline, Jacque Emilie, de Romeuf Christophe, Fontayne Alexandre, Abache Toufik, Fournier Nathalie, Dupont Gilles, Derache Delphine, Engrand Anais, Bauduin Aurélie, Terrier Aurélie, Seifert Alexander, Beghin Cécile, Longue Alain, Masiello Nicholas, Danino Laetitia, Nogre Michel, Raia Anais, Dhainaut Frederic, Fauconnier Louis, Togbe Dieudonnée, Reitinger Carmen, Nimmerjahn Falk, Stevens Wil, Chtourou Sami, Mondon Philippe
Abstract excerpt
Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies. Mutated Fc regions and monoclonal antibodies that target FcRn are currently in clinical development and hold promise for reducing the levels of circulating IgG. Additionally, engineered structures containing...
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