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Article

Pemphigus mouse model as a tool to evaluate various immunosuppressive therapies.

Experimental dermatology - 1 Mar 2009

Takae Yujiro, Nishikawa Takeji, Amagai Masayuki

Abstract excerpt

Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by immunoglobulin G (IgG) autoantibodies against desmoglein 3 (Dsg3). We have generated an active disease mouse model for PV by adoptive transfer of Dsg3(-/-) lymphocytes. In this study, we investigated the benefits and limitations of this model as a tool to evaluate various immunosuppressive therapeutic strategies. We used the following three...

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Source

Identifiers

PMID: 18643850
DOI: 10.1111/j.1600-0625.2008.00776.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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